We aimed to determine whether the retina and optic nerve are affected in liver dysfunctions in our study. Similarly, macular and choroidal analyzes using OCT in retinal diseases are helpful in early diagnosis. GCL and RNFL are the first parameters to deteriorate in optic nerve pathologies. Ĭhanges in ganglion cell layer (GCL++), retinal nerve fiber layer (RNFL), macular and choroidal thickness detected by optical coherence tomography (OCT) are helpful in the early diagnosis of ocular diseases. Conjunctiva, cornea, lens, retina and optic nerve are affected in liver diseases. Ocular findings can be detected at any age from birth due to blockage of certain metabolic pathways or accumulation of toxic substances in liver diseases. The liver is a very important metabolic center. The most common association is Sjögren’s syndrome (31%). PBC is often coexists with other autoimmune diseases. Alkaline phosphatase (ALP) levels are 1.5 times above the upper limit of normal for 24 weeks. Non-suppurative destructive cholangitis and interlobular bile duct destruction is detected on liver biopsy. In particular, the M2 distribution of AMA is important in confirmation of the diagnosis in patients with PBC. Chronic cholestasis and circulating anti-mitochondrial antibodies (AMA) are present in PBC. Patients with PBC are frequently female (90%) and the age at diagnosis is usually more than 40. Primary biliary cirrhosis (PBC) is an choronic progressive autoimmune liver disease. OCT analyzes should be evaluated during periodic ocular examinations of PBC patients. OCT analyzes revealed thinning in CMT, CT and GCL++ in patients with liver dysfunction. INR (p=0.017) and PLT (p=0.027) values were lower in the PBC group. The choroidal vascular index (CVI) was also obtained. RNFL, Inferior RNFL (IRNFL), Superior RNFL (SRNFL), GCL++, CMT and CT were measured by swept source optical coherence tomography (OCT). Blood Alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), total bilirubin, albumin, prothrombin time results as the international normalized ratio (INR), neutrophil (NEUT), lymphocyte (LYMP), neutrophil lymphocyte rate (NLR), platelet (PLT), mean platelet volume (MPV) levels were analyzed in both groups. Methodsįifty two patients with Primary biliary cirrhosis (PBC group) and 61 healthy individuals (Control group) were included in our study. We aimed on evaluating the effect of liver dysfunction on retinal nerve fiber layer (RNFL), GCL++ (Ganglion cell layer + RNFL + Inner plexiform layer), central macular thickness (CMT) and subfoveal choroidal thickness (CT) measurements.
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